U.S. Residents
Juvenile Myelomonocytic Leukemia (JMML)
Juvenile Myelomonocytic Leukaemia (JMML) is a rare Myelodysplastic/Myeloproliferative disease that occurs in infants, young children, and occasionally adolescents. This Ph chromosome-negative (Ph-) clonal disorder is characterized by proliferation of neutrophilic and monocytic lineages.1
Epidemiology
JMML accounts for about 2% of all childhood leukaemias.2 The disorder typically presents in young children (median age approximately 1 year); it occurs more commonly in boys than in girls (male to female ratio approximately 2.5:1). Children with neurofibromatosis type 1 (NF1) are at increased risk for the development of JMML.2
References:
1. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292-2302.
2. National Cancer Institute. Myelodysplastic/Myeloproliferative Diseases (PDQ®): Treatment. Health Professional Version. Available at: http://www.cancer.gov/cancertopics/pdq/treatment /mds-mpd/healthprofessional/allpages. Accessed February 3, 2009.