U.S. ResidentsGLIVEC AND ADDITIONAL INDICATIONS
GLIVEC is also indicated for the treatment of adult patients with1:
- Newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) integrated with chemotherapy
- Relapsed or refractory Ph+ ALL as monotherapy
- Myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with platelet-derived growth factor receptor (PDGFR) gene rearrangements
- Advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) with FIP1L1-PDGFRα rearrangement
- Unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery
Despite the low incidence of these diseases, the impact is profound2,3,4,5,6
For affected patients, these disorders result in:
- Substantial morbidity and reduced quality of life2,4,5,6
- A heavy economic burden for patients and their families
Medical information can be scarce
Because of the low prevalence of these diseases, comprehensive medical information is often hard to obtain. This section of the Web site is intended to help strengthen your understanding of the diagnosis and treatment of these disorders.
References
- Glivec® (imatinib) summary of product characteristics. West Sussex, UK: Novartis Europharm Limited; 2010.
- Karnak D, Kayacan O, Beder S, Delibalta M. Hypereosinophilic syndrome with pulmonary and cardiac involvement in a patient with asthma. CMAJ. 2003;168(2):172-175.
- Gloster HM Jr. Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996;35(3, pt1):355-374; quiz 375-376.
- Hernández JM, del Cañizo MC, Cuneo A, et al. Clinical, hematological and cytogenetic characteristics of atypical chronic myeloid leukemia. Ann Oncol. 2000;11(4):441-444.
- Swansbury J. The myeloid disorders: background. In: Swansbury J, ed. Cancer Cytogenetics: Methods and Protocols. Vol 220. Totowa, NJ: Humana Press;2003:23-42.
- McArthur G. Molecularly targeted treatment for dermatofibrosarcoma protuberans. Semin Oncol. 2004;31(2)(suppl 6):30-36.
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